Mechanismen der Makrophagen-Aktivierung in Connexin32-defizienten Mäusen
Mechanisms of Macrphage Activation in Connexin32 deficient mice
Please always quote using this URN: urn:nbn:de:bvb:20-opus-27491
- Connexin32- defiziente Mäuse stellen ein Mausmodell für eine Form der hereditären peripheren Neuropahtie dar. Es konnte gezeigt werden, dass Makrophagen, möglicherweise aktiviert durch MCP-1, die Demyelinisierung in Connexin32-defizienten Mäusen vermitteln. Diese Arbeit untersucht mögliche Signaltransduktionswege, die in den peripheren Nerven Connexin32- defizienter Mäuse aktiviert sein könnten und damit in Zusammenhang mit der Genexpression von MCP-1 und/oder Makrophagen-Aktivierung stehen könnten.
- Connexin32 deficient mice are a well established mouse model for the hereditary neuropathy known as Charcot-Marie-Tooth disease. Recently it was shown that macrophages function as the mediators of demyelination in peripheral nerves. Additionally there was found an icreased gene expression of MCP-1 in peripheral nerves of these animals. This study tries to identify un activated signal transduction pathway in peripheral nerves of Connexin32 deficient mice that may lead to the increased gene expression of MCP-1 and increased number of macrophagesConnexin32 deficient mice are a well established mouse model for the hereditary neuropathy known as Charcot-Marie-Tooth disease. Recently it was shown that macrophages function as the mediators of demyelination in peripheral nerves. Additionally there was found an icreased gene expression of MCP-1 in peripheral nerves of these animals. This study tries to identify un activated signal transduction pathway in peripheral nerves of Connexin32 deficient mice that may lead to the increased gene expression of MCP-1 and increased number of macrophages in peripheral nerves of Connexin32 deficient mice.…
Author: | Juliane Greeske |
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URN: | urn:nbn:de:bvb:20-opus-27491 |
Document Type: | Doctoral Thesis |
Granting Institution: | Universität Würzburg, Medizinische Fakultät |
Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Date of final exam: | 2008/05/09 |
Language: | German |
Year of Completion: | 2008 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Makrophage; Immunoblot; Peripheres Nervensystem |
Tag: | Connexin32-defiziente Maus; MCP-1; Sigaltransduktionsweg; hereditäre periphere Neuropathie Connexin32 deficient mice; MCP-1; hereditary neuropathy; signal transduction pathway |
Release Date: | 2008/05/19 |
Advisor: | Prof. Dr. rer. nat. Rudolf Martini |