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Allatostatin A signalling: progress and new challenges from a paradigmatic pleiotropic invertebrate neuropeptide family
Please always quote using this URN: urn:nbn:de:bvb:20-opus-278749
- Neuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. In insects and other panarthropods, AstA peptides qualify as brain-gut peptides and have regained attention with the discovery of their role in regulating feeding, growth, activity/sleep and learning. AstA receptor homologs are found throughout theNeuropeptides have gained broad attraction in insect neuroscience and physiology, as new genetic tools are increasingly uncovering their wide-ranging pleiotropic functions with high cellular resolution. Allatostatin A (AstA) peptides constitute one of the best studied insect neuropeptide families. In insects and other panarthropods, AstA peptides qualify as brain-gut peptides and have regained attention with the discovery of their role in regulating feeding, growth, activity/sleep and learning. AstA receptor homologs are found throughout the protostomia and group with vertebrate somatostatin/galanin/kisspeptin receptors. In this review, we summarise the current knowledge on the evolution and the pleiotropic and cell-specific non-allatostatic functions of AstA. We speculate about the core functions of AstA signalling, and derive open questions and challengesfor future research on AstA and invertebrate neuropeptides in general.…
Author: | Christian Wegener, Jiangtian Chen |
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URN: | urn:nbn:de:bvb:20-opus-278749 |
Document Type: | Journal article |
Faculties: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Language: | English |
Parent Title (English): | Frontiers in Physiology |
ISSN: | 1664-042X |
Year of Completion: | 2022 |
Volume: | 13 |
Article Number: | 920529 |
Source: | Frontiers in Physiology (2022) 13:920529. doi:10.3389/fphys.2022.920529 |
DOI: | https://doi.org/10.3389/fphys.2022.920529 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Tag: | cardioactive factor; feeding; intestinal control; kisspeptin/galanin/spexin signalling; learning; metabolism and growth; neuropeptide signalling; sleep/activity |
Release Date: | 2023/04/18 |
Date of first Publication: | 2022/06/24 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |