Alveolar regeneration in COVID-19 patients: a network perspective
Please always quote using this URN: urn:nbn:de:bvb:20-opus-284307
- A viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes inA viral infection involves entry and replication of viral nucleic acid in a host organism, subsequently leading to biochemical and structural alterations in the host cell. In the case of SARS-CoV-2 viral infection, over-activation of the host immune system may lead to lung damage. Albeit the regeneration and fibrotic repair processes being the two protective host responses, prolonged injury may lead to excessive fibrosis, a pathological state that can result in lung collapse. In this review, we discuss regeneration and fibrosis processes in response to SARS-CoV-2 and provide our viewpoint on the triggering of alveolar regeneration in coronavirus disease 2019 (COVID-19) patients.…
Author: | Shishir K. Gupta, Mugdha Srivastava, Rashmi Minocha, Aman Akash, Seema Dangwal, Thomas Dandekar |
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URN: | urn:nbn:de:bvb:20-opus-284307 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften | |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2021 |
Volume: | 22 |
Issue: | 20 |
Article Number: | 11279 |
Source: | International Journal of Molecular Sciences (2021) 22:20, 11279. https://doi.org/10.3390/ijms222011279 |
DOI: | https://doi.org/10.3390/ijms222011279 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | COVID-19; SARS-CoV-2; alveolar fibrosis; alveolar regeneration; network biology; signaling pathway |
Release Date: | 2023/07/10 |
Date of first Publication: | 2021/10/19 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |