Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon Stamp, Karl-Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. Kapur, Sebastian K. King, Conor J. McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe
- Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENSOver the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.…
MetadatenAuthor: | Alan J. Burns, Allan M. Goldstein, Donald F. Newgreen, Lincon Stamp, Karl-Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M. Young, Peter W. Andrews, Nikhil Thapar, Jaime Belkind-Gerson, Nadege Bondurand, Joel C. Bornstein, Wood Yee Chan, Kathryn Cheah, Michael D. Gershon, Robert O. Heuckeroth, Robert M.W. Hofstra, Lothar Just, Raj P. Kapur, Sebastian K. King, Conor J. McCann, Nandor Nagy, Elly Ngan, Florian Obermayr, Vassilis Pachnis, Pankaj J. Pasricha, Mai Har Sham, Paul Tam, Pieter Vanden Berghe |
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URN: | urn:nbn:de:bvb:20-opus-187415 |
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Document Type: | Journal article |
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Faculties: | Medizinische Fakultät / Lehrstuhl für Tissue Engineering und Regenerative Medizin |
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Language: | English |
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Parent Title (English): | Developmental Biology |
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Year of Completion: | 2016 |
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Volume: | 417 |
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Issue: | 2 |
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Pagenumber: | 229-251 |
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Source: | Developmental Biology (2016) 417:2, 229-251. https://doi.org/10.1016/j.ydbio.2016.04.001 |
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DOI: | https://doi.org/10.1016/j.ydbio.2016.04.001 |
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Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Tag: | Cell replacement therapy; Enteric nervous system; Enteric neuropathies; Hirschsprung disease; Hirschsprung disease liability; Hypertrophic pyloric-stenosis; In-vivo; Intestinal pseudoobstruction; Neural crest cells; Nitric-oxide; Oxide synthase gene; Rat mynteric plexus; Slow-transit constipation; Stem cells; Term follow-up |
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Release Date: | 2020/06/16 |
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Licence (German): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |
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