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Architecture and expression of the Nfatc1 gene in lymphocytes

Please always quote using this URN: urn:nbn:de:bvb:20-opus-112718
  • In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca++, the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc proteins. In addition to rapid activation of NFAT factors, immune receptor signals lead to accumulation of the short NFATc1/αA isoform in lymphocytes which controls their proliferation and survival. In this mini-review, we summarize ourIn lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1), and NFATc3 (NFAT4 or NFATx) are expressed and are the targets of immune receptor signals, which lead to a rapid rise of intracellular Ca++, the activation of phosphatase calcineurin, and to the activation of cytosolic NFATc proteins. In addition to rapid activation of NFAT factors, immune receptor signals lead to accumulation of the short NFATc1/αA isoform in lymphocytes which controls their proliferation and survival. In this mini-review, we summarize our current knowledge on the structure and transcription of the Nfatc1 gene in lymphocytes, which is controlled by two promoters, two poly A addition sites and a remote downstream enhancer. The Nfatc1 gene resembles numerous primary response genes (PRGs) induced by LPS in macrophages. Similar to the PRG promoters, the Nfatc1 promoter region is organized in CpG islands, forms DNase I hypersensitive sites, and is marked by histone tail modifications before induction. By studying gene induction in lymphocytes in detail, it will be important to elucidate whether the properties of the Nfatc1 induction are not only typical for the Nfatc1 gene but also for other transcription factor genes expressed in lymphocytes.show moreshow less

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Metadaten
Author: Edgar Serfling, Ronald Rudolf, Rhoda Busch, Amiya K. Patra, Khalid Muhammad, Andris Avots, Jean-Christophe Andrau, Stefan Klein-Hessling
URN:urn:nbn:de:bvb:20-opus-112718
Document Type:Journal article
Faculties:Medizinische Fakultät / Pathologisches Institut
Language:English
Year of Completion:2014
Source:Frontiers in Immunology 5:21 (2014). doi: 10.3389/fimmu.2014.00021
DOI:https://doi.org/10.3389/fimmu.2014.00021
Sonstige beteiligte Institutionen:Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Nfatc1; chromatin; induction; lymphocytes; transcription
Release Date:2015/05/12
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2014
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung