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Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease

Please always quote using this URN: urn:nbn:de:bvb:20-opus-285014
  • The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating theThe receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells. There is also evidence that EMMPRIN controls energy metabolism of cells and that EMMPRIN binding partners modulate intracellular glycosylation and trafficking of EMMPRIN towards the cell membrane. In this review, we systematically discuss these multifaceted roles of EMMPRIN and its interaction partners, such as Cyclophilins, in cardiovascular disease.show moreshow less

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Metadaten
Author: Saskia N. I. von Ungern-Sternberg, Alma Zernecke, Peter Seizer
URN:urn:nbn:de:bvb:20-opus-285014
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Experimentelle Biomedizin
Language:English
Parent Title (English):International Journal of Molecular Sciences
ISSN:1422-0067
Year of Completion:2018
Volume:19
Issue:2
Article Number:507
Source:International Journal of Molecular Sciences (2018) 19:2, 507. https://doi.org/10.3390/ijms19020507
DOI:https://doi.org/10.3390/ijms19020507
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:cardiovascular disease; immunoglobulin superfamily; inflammation; monocyte-platelet aggregates; platelets
Release Date:2023/05/31
Date of first Publication:2018/02/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International