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IgG monoclonal antibodies that inhibit osteoinductivity of human bone matrix-derived proteins (hBMP/NCP)

Please always quote using this URN: urn:nbn:de:bvb:20-opus-62388
  • Monoclonal hBMP/NCP (human bone morphogenetic protein anrl associaterl noncollagenous proteins) antiborlies of the lgG class were prorlucerl. In vitro, 12 of 19 hBMP/NCP antiborlies showerl functional inhibition of hBMP/ NCP-induced chondroneogenesis in a neonatal muscle tissue assay. Inducing factors were characterized by their inhibiting antibodies with immunoblotting. Several peptide factors seem to be involved in the cascade of inducerl chondro- and osteogenesis.

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Author: N. Kübler, J. Reuther, T. Kirchner, M. Pfaff, H. K. Müller-Hermelink, R. Albert, Walter Sebald
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Year of Completion:1994
Source:In: International journal of oral and maxillofacial surgery (1994 Dec) 23, 6 part 2, 420-422.
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
GND Keyword:Biochemie
Tag:bone morphogenetic proteins; cartilage induction; neutralizing antibodies
Release Date:2012/03/16
Licence (German):License LogoDeutsches Urheberrecht