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Association of transcription factor APRF and protein kinase JAK1 with the IL-6 signal transducer gp130

Please always quote using this URN: urn:nbn:de:bvb:20-opus-42577
  • Interleukin-6, leukemia inhibitory factor, oncostatin M. Interleukin-11, and cilialy neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenicaly relaled to the p91 subunit of the interferon-stimulated gene factor-(ISGF-3a). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3a p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1Interleukin-6, leukemia inhibitory factor, oncostatin M. Interleukin-11, and cilialy neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenicaly relaled to the p91 subunit of the interferon-stimulated gene factor-(ISGF-3a). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3a p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.show moreshow less

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Metadaten
Author: Claudia Lütticken, Ursula M. Wegenka, Juping Yuan, Jan Buschmann, Chris Schindler, Andrew Ziemiecki, Alisa G. Harpur, Andrew F. Wilks, Kiyoshi Yasukawa, Tetsuya Taga, Tadamitsu Kishimoto, Giovanna Barbieri, Michael Sendtner, Sandra Pellegrini, Peter C. Heinrich, Friedemann Horn
URN:urn:nbn:de:bvb:20-opus-42577
Document Type:Report
Faculties:Medizinische Fakultät / Institut für Klinische Neurobiologie
Language:English
Year of Completion:1994
Source:In: Science, 1994, 263, 89 - 92.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Release Date:2010/01/27