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Characterization of Sex Determination and Sex Differentiation Genes in Latimeria

Please always quote using this URN: urn:nbn:de:bvb:20-opus-130995
  • Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique "living fossils", could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome ofGenes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique "living fossils", could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of Latimeria chalumnae and from the liver and testis transcriptomes of Latimeria menadoensis, implicated in sex determination and differentiation, were identified and characterized and their expression levels measured. Interesting findings were obtained for GSDF, previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage; FGF9, which is not found in teleosts; and DMRT1, whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development.show moreshow less

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Metadaten
Author: Mariko Forconi, Adriana Canapa, Marco Barucca, Maria A. Biscotti, Teresa Capriglione, Francesco Buonocore, Anna M. Fausto, Daisy M. Makapedua, Alberto Pallavicini, Marco Gerdol, Gianluca De Moro, Giuseppe Scapigliati, Ettore Olmo, Manfred Schartl
URN:urn:nbn:de:bvb:20-opus-130995
Document Type:Journal article
Faculties:Medizinische Fakultät / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):PLoS ONE
Year of Completion:2013
Volume:8
Issue:4
Pagenumber:e56006
Source:PLoS ONE 8(4): e56006. doi:10.1371/journal.pone.0056006
DOI:https://doi.org/10.1371/journal.pone.0056006
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:DM-domain gene; dimorphic expression; genomic organization; medaka fish; molecular mechanisms; monodelphis domestica; mullerian hormone AMH; oreochromis niloticus; oryzias latipes; regulatory regions
Release Date:2016/05/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung