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Eye infections caused by filamentous fungi: spectrum and antifungal susceptibility of the prevailing agents in Germany

Please always quote using this URN: urn:nbn:de:bvb:20-opus-241810
  • Fungal eye infections can lead to loss of vision and blindness. The disease is most prevalent in the tropics, although case numbers in moderate climates are increasing as well. This study aimed to determine the dominating filamentous fungi causing eye infections in Germany and their antifungal susceptibility profiles in order to improve treatment, including cases with unidentified pathogenic fungi. As such, we studied all filamentous fungi isolated from the eye or associated materials that were sent to the NRZMyk between 2014 and 2020. AllFungal eye infections can lead to loss of vision and blindness. The disease is most prevalent in the tropics, although case numbers in moderate climates are increasing as well. This study aimed to determine the dominating filamentous fungi causing eye infections in Germany and their antifungal susceptibility profiles in order to improve treatment, including cases with unidentified pathogenic fungi. As such, we studied all filamentous fungi isolated from the eye or associated materials that were sent to the NRZMyk between 2014 and 2020. All strains were molecularly identified and antifungal susceptibility testing according to the EUCAST protocol was performed for common species. In total, 242 strains of 66 species were received. Fusarium was the dominating genus, followed by Aspergillus, Purpureocillium, Alternaria, and Scedosporium. The most prevalent species in eye samples were Fusarium petroliphilum, F. keratoplasticum, and F. solani of the Fusarium solani species complex. The spectrum of species comprises less susceptible taxa for amphotericin B, natamycin, and azoles, including voriconazole. Natamycin is effective for most species but not for Aspergillus flavus or Purpureocillium spp. Some strains of F. solani show MICs higher than 16 mg/L. Our data underline the importance of species identification for correct treatment.show moreshow less

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Metadaten
Author: Grit Walther, Anna Zimmermann, Johanna Theuersbacher, Kerstin Kaerger, Marie von Lilienfeld-Toal, Mathias Roth, Daniel Kampik, Gerd Geerling, Oliver Kurzai
URN:urn:nbn:de:bvb:20-opus-241810
Document Type:Journal article
Faculties:Medizinische Fakultät / Augenklinik und Poliklinik
Medizinische Fakultät / Institut für Hygiene und Mikrobiologie
Language:English
Parent Title (English):Journal of Fungi
ISSN:2309-608X
Year of Completion:2021
Volume:7
Issue:7
Article Number:511
Source:Journal of Fungi (2021) 7:7, 511. https://doi.org/10.3390/jof7070511
DOI:https://doi.org/10.3390/jof7070511
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Alternaria; Aspergillus; Fusarium; Purpureocillium; Scedosporium; antifungal susceptibility; eye infection; fungal infection; keratitis; natamycin
Release Date:2023/05/24
Date of first Publication:2021/06/26
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International