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Distinct functions of specialized dendritic cell subsets in atherosclerosis and the road ahead

Please always quote using this URN: urn:nbn:de:bvb:20-opus-120241
  • Atherosclerotic vascular disease is modulated by immune mechanisms. Dendritic cells (DCs) and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development, namely, that of CCL17-expressing DCs as well as that of plasmacytoid DCs that play specialized roles in disease development. This review focuses on important findings gathered in these studies andAtherosclerotic vascular disease is modulated by immune mechanisms. Dendritic cells (DCs) and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development, namely, that of CCL17-expressing DCs as well as that of plasmacytoid DCs that play specialized roles in disease development. This review focuses on important findings gathered in these studies and dissects the multifaceted contribution of CCL17-expressing DCs and pDCs to the pathogenesis of atherosclerosis. Furthermore, an outlook on future challenges faced when studying DCs in this detrimental disease are provided, and hurdles that will need to be overcome in order to enable a better understanding of the contribution of DCs to atherogenesis are discussed, a prerequisite for their therapeutic targeting in atherosclerosis.show moreshow less

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Metadaten
Author: Alma Zernecke
URN:urn:nbn:de:bvb:20-opus-120241
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Klinische Biochemie und Pathobiochemie
Language:English
Parent Title (English):Scientifica
Year of Completion:2014
Volume:2014
Pagenumber:952625
Source:Scientifica Volume 2014, Article ID 952625, 7 pages DOI 10.1155/2014/952625
DOI:https://doi.org/10.1155/2014/952625
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:atherosclerotic vascular disease
Release Date:2016/02/11
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung