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Characterization of the env gene and of two novel coding regions of the human spumaretrovirus

Please always quote using this URN: urn:nbn:de:bvb:20-opus-86334
  • Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open readingRecombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes.show moreshow less

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Metadaten
Author: B. Maurer, H. Bannert, Axel Rethwilm, B. Darai, R. M. Flügel
URN:urn:nbn:de:bvb:20-opus-86334
Document Type:Conference Proceeding
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Language:English
Year of Completion:1988
Source:In: Human Retroviruses, cancer, and aids / ed. Dani Bolognesi. - New York: Liss, 1988.- S. 75-88. - (Symposium on Molecular and Cellular Biology: UCLA Symposia on Molecular and Cellular Biology / New ser. ; 71. ). - ISBN 0-8451-2670-9
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Spumaviren
Release Date:2014/06/12
Licence (German):License LogoDeutsches Urheberrecht