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Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability

Please always quote using this URN: urn:nbn:de:bvb:20-opus-130631
  • Animals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shockAnimals acquire predictive values of sensory stimuli through reinforcement. In the brain of Drosophila melanogaster, activation of two types of dopamine neurons in the PAM and PPL1 clusters has been shown to induce aversive odor memory. Here, we identified the third cell type and characterized aversive memories induced by these dopamine neurons. These three dopamine pathways all project to the mushroom body but terminate in the spatially segregated subdomains. To understand the functional difference of these dopamine pathways in electric shock reinforcement, we blocked each one of them during memory acquisition. We found that all three pathways partially contribute to electric shock memory. Notably, the memories mediated by these neurons differed in temporal stability. Furthermore, combinatorial activation of two of these pathways revealed significant interaction of individual memory components rather than their simple summation. These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory.show moreshow less

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Metadaten
Author: Yoshinori Aso, Andrea Herb, Maite Ogueta, Igor Siwanowicz, Thomas Templier, Anja B. Friedrich, Kei Ito, Henrike Scholz, Hiromu Tanimoto
URN:urn:nbn:de:bvb:20-opus-130631
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):PLoS Genetics
Year of Completion:2012
Volume:8
Issue:7
Pagenumber:e1002768
Source:PLoS Genetics 8(7): e1002768. doi:10.1371/journal.pgen.1002768
DOI:https://doi.org/10.1371/journal.pgen.1002768
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 576 Genetik und Evolution
Tag:drosophila mushroom body; dynamics; expression; localization; long-term-memory; melanogaster; neurons form; olfactory memory; sensitization; serotonin
Release Date:2016/11/28
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung