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Treatment-independent miRNA signature in blood of wilms tumor patients

Please always quote using this URN: urn:nbn:de:bvb:20-opus-124034
  • Background Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001. Results We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patientsBackground Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001. Results We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls. Conclusion Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of four weeks preoperative chemotherapy treatment.show moreshow less

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Metadaten
Author: Jana Schmitt, Christina Backes, Nasenien Nourkami-Tutdibi, Petra Leidinger, Stephanie Deutscher, Markus Beier, Manfred Gessler, Norbert Graf, Hans-Peter Lenhof, Andreas Keller, Eckart Meese
URN:urn:nbn:de:bvb:20-opus-124034
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):BMC Genomics
Year of Completion:2012
Volume:13
Issue:379
Source:BMC Genomics 2012, 13:379. doi:10.1186/1471-2164-13-379
DOI:https://doi.org/10.1186/1471-2164-13-379
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 611 Menschliche Anatomie, Zytologie, Histologie
Tag:miRNA
Release Date:2016/01/13
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung