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A Nasal Epithelial Receptor for Staphylococcus aureus WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization

Please always quote using this URN: urn:nbn:de:bvb:20-opus-116280
  • Nasal colonization is a major risk factor for S. aureus infections. The mechanisms responsible for colonization are still not well understood and involve several factors on the host and the bacterial side. One key factor is the cell wall teichoic acid (WTA) of S. aureus, which governs direct interactions with nasal epithelial surfaces. We report here the first receptor for the cell wall glycopolymer WTA on nasal epithelial cells. In several assay systems this type F-scavenger receptor, termed SREC-I, bound WTA in a charge dependent manner andNasal colonization is a major risk factor for S. aureus infections. The mechanisms responsible for colonization are still not well understood and involve several factors on the host and the bacterial side. One key factor is the cell wall teichoic acid (WTA) of S. aureus, which governs direct interactions with nasal epithelial surfaces. We report here the first receptor for the cell wall glycopolymer WTA on nasal epithelial cells. In several assay systems this type F-scavenger receptor, termed SREC-I, bound WTA in a charge dependent manner and mediated adhesion to nasal epithelial cells in vitro. The impact of WTA and SREC-I interaction on epithelial adhesion was especially pronounced under shear stress, which resembles the conditions found in the nasal cavity. Most importantly, we demonstrate here a key role of the WTA-receptor interaction in a cotton rat model of nasal colonization. When we inhibited WTA mediated adhesion with a SREC-I antibody, nasal colonization in the animal model was strongly reduced at the early onset of colonization. More importantly, colonization stayed low over an extended period of 6 days. Therefore we propose targeting of this glycopolymer-receptor interaction as a novel strategy to prevent or control S. aureus nasal colonization.show moreshow less

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Metadaten
Author: Stefanie Baur, Maren Rautenberg, Manuela Faulstich, Timo Grau, Yannik Severin, Clemens Unger, Wolfgang H. Hoffmann, Thomas Rudel, Ingo B. Autenrieth, Christopher Weidenmaier
URN:urn:nbn:de:bvb:20-opus-116280
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):PLOS PATHOGENS
ISSN:1553-7374
Year of Completion:2014
Volume:10
Issue:5
Pagenumber:e1004089
Source:PLoS Pathogens 10(5): e1004089. doi:10.1371/journal.ppat.1004089
DOI:https://doi.org/10.1371/journal.ppat.1004089
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24788600
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:SREC-I; carriage; clumping factor-B; cotton rats; determinant; expression; infections; scavender receptor; surface proteins; teichoic acids
Release Date:2015/07/30
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung