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ALVIS: interactive non-aggregative visualization and explorative analysis of multiple sequence alignments

Please always quote using this URN: urn:nbn:de:bvb:20-opus-166374
  • Sequence Logos and its variants are the most commonly used method for visualization of multiple sequence alignments (MSAs) and sequence motifs. They provide consensus-based summaries of the sequences in the alignment. Consequently, individual sequences cannot be identified in the visualization and covariant sites are not easily discernible. We recently proposed Sequence Bundles, a motif visualization technique that maintains a one-to-one relationship between sequences and their graphical representation and visualizes covariant sites. We hereSequence Logos and its variants are the most commonly used method for visualization of multiple sequence alignments (MSAs) and sequence motifs. They provide consensus-based summaries of the sequences in the alignment. Consequently, individual sequences cannot be identified in the visualization and covariant sites are not easily discernible. We recently proposed Sequence Bundles, a motif visualization technique that maintains a one-to-one relationship between sequences and their graphical representation and visualizes covariant sites. We here present Alvis, an open-source platform for the joint explorative analysis of MSAs and phylogenetic trees, employing Sequence Bundles as its main visualization method. Alvis combines the power of the visualization method with an interactive toolkit allowing detection of covariant sites, annotation of trees with synapomorphies and homoplasies, and motif detection. It also offers numerical analysis functionality, such as dimension reduction and classification. Alvis is user-friendly, highly customizable and can export results in publication-quality figures. It is available as a full-featured standalone version (http://www.bitbucket.org/rfs/alvis) and its Sequence Bundles visualization module is further available as a web application (http://science-practice.com/projects/sequence-bundles).show moreshow less

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Metadaten
Author: Roland F. Schwarz, Asif U. Tamuri, Marek Kultys, James King, James Godwin, Ana M. Florescu, Jörg Schultz, Nick Goldman
URN:urn:nbn:de:bvb:20-opus-166374
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Nucleic Acids Research
Year of Completion:2016
Volume:44
Issue:8
Pagenumber:e77
Source:Nucleic Acids Research, 2016, Vol. 44, No. 8, e77. DOI: 10.1093/nar/gkw022
DOI:https://doi.org/10.1093/nar/gkw022
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:Alvis; multiple sequence alignments; phylogenetic trees; visualization
Release Date:2019/07/05
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International