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Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila

Please always quote using this URN: urn:nbn:de:bvb:20-opus-170831
  • Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone,Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.show moreshow less

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Metadaten
Author: Mareike Selcho, Carola Millán, Angelina Palacios-Muñoz, Franziska Ruf, Lilian Ubillo, Jiangtian Chen, Gregor Bergmann, Chihiro Ito, Valeria Silva, Christian Wegener, John Ewer
URN:urn:nbn:de:bvb:20-opus-170831
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Nature Communications
Year of Completion:2017
Volume:8
Issue:15563
Source:Nature Communications 2017, 8:15563. DOI: 10.1038/ncomms15563
DOI:https://doi.org/10.1038/ncomms15563
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28555616
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:Drosophila; central clocks; circadian clock; neuropeptide pathway; peripheral clocks
Release Date:2019/10/11
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International