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Metabolic silencing via methionine-based amino acid restriction in head and neck cancer

Please always quote using this URN: urn:nbn:de:bvb:20-opus-319257
  • In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 newIn recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines.show moreshow less

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Metadaten
Author: Anna Chiara Wünsch, Elena Ries, Sina Heinzelmann, Andrea Frabschka, Peter Christoph Wagner, Theresa Rauch, Corinna Koderer, Mohamed El-Mesery, Julian Manuel Volland, Alexander Christian Kübler, Stefan Hartmann, Axel Seher
URN:urn:nbn:de:bvb:20-opus-319257
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
Language:English
Parent Title (English):Current Issues in Molecular Biology
ISSN:1467-3045
Year of Completion:2023
Volume:45
Issue:6
First Page:4557
Last Page:4573
Source:Current Issues in Molecular Biology (2023) 45:6, 4557-4573. https://doi.org/10.3390/cimb45060289
DOI:https://doi.org/10.3390/cimb45060289
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:HNSCC; SCCHN; SLC-family; amino acid restriction; amino acid transporter; caloric restriction; cell vitality; cisplatin; low energy metabolism; methionine
Release Date:2024/03/28
Date of first Publication:2023/05/24
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International