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Cryptochrome interacts with actin and enhances eye-mediated light sensitivity of the circadian clock in Drosophila melanogaster

Please always quote using this URN: urn:nbn:de:bvb:20-opus-177086
  • Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly Drosophila melanogaster CRY plays a light-independent role as “assembling” protein in the rhabdomeres of the compound eyes. CRY interacts with actin and appears to increase lightCryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of circadian rhythmicity. Moreover, CRYs are sensing magnetic fields in insects as well as in humans. Here, we show that in the fruit fly Drosophila melanogaster CRY plays a light-independent role as “assembling” protein in the rhabdomeres of the compound eyes. CRY interacts with actin and appears to increase light sensitivity of the eyes by keeping the “signalplex” of the phototransduction cascade close to the membrane. By this way, CRY also enhances light-responses of the circadian clock.show moreshow less

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Metadaten
Author: Matthias Schlichting, Dirk Rieger, Paola Cusumano, Rudi Grebler, Rodolfo Costa, Gabriella M. Mazzotta, Charlotte Helfrich-Förster
URN:urn:nbn:de:bvb:20-opus-177086
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Frontiers in Molecular Neuroscience
Year of Completion:2018
Volume:11
Issue:238
Source:Frontiers in Molecular Neuroscience 2018, Volume 11, Article 238. DOI: 10.3389/fnmol.2018.00238
DOI:https://doi.org/10.3389/fnmol.2018.00238
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:Drosophila melanogaster; F-actin; activity rhythms; cryptochrome; phototransduction
Release Date:2019/02/27
EU-Project number / Contract (GA) number:018741
OpenAIRE:OpenAIRE
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2018
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International