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Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men

Please always quote using this URN: urn:nbn:de:bvb:20-opus-179870
  • Meningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany andMeningococci spread via respiratory droplets, whereas the closely related gonococci are transmitted sexually. Several outbreaks of invasive meningococcal disease have been reported in Europe and the United States among men who have sex with men (MSM). We recently identified an outbreak of serogroup C meningococcal disease among MSM in Germany and France. In this study, genomic and proteomic techniques were used to analyze the outbreak isolates. In addition, genetically identical urethritis isolates were recovered from France and Germany and included in the analysis. Genome sequencing revealed that the isolates from the outbreak among MSM and from urethritis cases belonged to a clade within clonal complex 11. Proteome analysis showed they expressed nitrite reductase, enabling anaerobic growth as previously described for gonococci. Invasive isolates from MSM, but not urethritis isolates, further expressed functional human factor H binding protein associated with enhanced survival in a newly developed transgenic mouse model expressing human factor H, a complement regulatory protein. In conclusion, our data suggest that urethritis and outbreak isolates followed a joint adaptation route including adaption to the urogenital tract.show moreshow less

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Metadaten
Author: Muhamed-Kheir Taha, Heike Claus, Martin Lappann, Frédéric J. Veyrier, Andreas Otto, Dörte Becher, Ala-Eddine Deghmane, Matthias Frosch, Wiebke Hellenbrand, Eva Hong, Isabelle Parent du Châtelet, Karola Prior, Dag Harmsen, Ulrich Vogel
URN:urn:nbn:de:bvb:20-opus-179870
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Hygiene und Mikrobiologie
Language:English
Parent Title (English):PLoS ONE
Year of Completion:2016
Volume:11
Issue:5
Article Number:e0154047
Source:PLoS ONE 2016, 11(5):e0154047. DOI:10.1371/journal.pone.0154047
DOI:https://doi.org/10.1371/journal.pone.0154047
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Neisseria gonorrhoeae; Neisseria meningitidis; genome sequencing; mammalian genomics; men who have sex with men; meningococcal disease; mouse models; nitrites
Release Date:2020/12/14
EU-Project number / Contract (GA) number:278864
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International