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Rats Fed Diets with Different Energy Contribution from Fat Do Not Differ in Adiposity

Please always quote using this URN: urn:nbn:de:bvb:20-opus-115249
  • Objective: To determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition. Methods: In experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantifiedObjective: To determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition. Methods: In experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantified using magnetic resonance imaging (MRI), dissection, and plasma leptin. Results: In experiment 1, both groups reached similar final body mass at the same age; in experiment 2 the HFD group reached similar final body mass earlier than the LFD group. There were no significant differences in WAT as assessed by MRI or leptin between the HFD and LFD groups in both experiments. Dissection revealed a trend for higher retroperitoneal and epididymal adiposity in the HFD groups in both experiments. Conclusions: We conclude that at similar body mass, adiposity is independent of the macronutrient composition of the feeding regimen used to achieve it. (C) 2014 S Karger GmbH, Freiburgshow moreshow less

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Metadaten
Author: Alexander D. Miras, Florian Seyfried, Alkystis Phinikaridou, Marcelo E. Andia, Ioannis Christakis, Alan C. Spector, Rene M. Botnar, Carel W. le Roux
URN:urn:nbn:de:bvb:20-opus-115249
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Language:English
Parent Title (English):OBESITY FACTS
Year of Completion:2014
Volume:7
Issue:5
Pagenumber:302-310
Source:Obesity Facts 2014;7:302–310. DOI: 10.1159/000368622
DOI:https://doi.org/10.1159/000368622
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25277969
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:High-fat diet; Leptin; Low-fat diet; MRI; accumulation; body fat; expenditure; induced obesity; isocaloric intake; mass; metabolism; tissue; visceral fat; weight-gain
Release Date:2015/07/14
EU-Project number / Contract (GA) number:241592
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell