Effects of transcranial direct current stimulation on consolidation of fear memory
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- It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm, in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assignedIt has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm, in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal, and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 min after fear conditioning. The effect of fear conditioning and consolidation (24 h later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation.…
Autor(en): | Asthana Manish, Katharina Nueckel, Andreas Mühlberger, Dorothea Neueder, Thomas Polak, Katharina Domschke, Jürgen Deckert, Martin J. Herrmann |
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URN: | urn:nbn:de:bvb:20-opus-97294 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Neuropsychiatric Imaging and Stimulation |
Erscheinungsjahr: | 2013 |
Originalveröffentlichung / Quelle: | In:Frontiers in Neuropsychiatric Imaging and Stimulation (2013) 4: 107, doi:10.3389/fpsyt.2013.00107 |
DOI: | https://doi.org/10.3389/fpsyt.2013.00107 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | dorsolateral prefrontal cortex; fear conditioning; fear memory consolidation; transcranial direct current stimulation |
Datum der Freischaltung: | 07.05.2014 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2013 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |