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No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis

Please always quote using this URN: urn:nbn:de:bvb:20-opus-136281
  • Background: IL-12p40 plays an important role in the activation of the T-cell lines like Th17 and Th1-cells. Theses cells are crucial in the pathogenesis of juvenile idiopathic arthritis. A polymorphism in its promoter region and the genotype IL12p40 pro1.1 leads to a higher production of IL-12p40. We studied whether there is a difference in the distribution of the genotype in patients with JIA and the healthy population. Methods: In 883 patients and 321 healthy controls the IL-12p40 promoter genotype was identified by ARMS-PCR. Results:Background: IL-12p40 plays an important role in the activation of the T-cell lines like Th17 and Th1-cells. Theses cells are crucial in the pathogenesis of juvenile idiopathic arthritis. A polymorphism in its promoter region and the genotype IL12p40 pro1.1 leads to a higher production of IL-12p40. We studied whether there is a difference in the distribution of the genotype in patients with JIA and the healthy population. Methods: In 883 patients and 321 healthy controls the IL-12p40 promoter genotype was identified by ARMS-PCR. Results: There is no association of IL-12p40 pro polymorphism neither in patients with JIA compared to controls nor in subtypes of JIA compared to oligoarthritis. We found a non-significant tendency of a higher prevalence of the genotype pro1.1 in systemic arthritis (32.4 %) and in rheumatoid factor negative polyarthritis (30.5 %) and a lower pro1.1 genotype in persistent oligoarthritis (20.7 %) and in enthesitis-related arthritis (17 %). Likelihood of the occurrence of genotype IL12-p40 pro1.1 in patients with systemic arthritis (OR 1.722, CI 95 % 1.344-2.615, p 0.0129) and RF-negative polyarthritis (OR 1.576, CI 95 % 1.046-2.376, p 0.0367) compared to persistent oligoarthritis was significantly higher. This was also true for comparison of their homozygous genotypes IL-12p40 pro 1.1 and 2.2 in systemic arthritis (OR 1.779, CI 95 % 1.045-3.029, p 0.0338). However, in Bonferroni correction for multiple hypothesis this was not significant. Conclusion: A tendency of a higher prevalence of the genotype IL-12p40 pro1.1 in systemic arthritis and in rheumatoid factor negative polyarthritis was observed but not significant. Further investigations should be done to clarify the role IL-12p40 in the different subtypes of JIA.show moreshow less

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Metadaten
Author: Christiane S. Eberhardt, Johannes-Peter Haas, Hermann Girschick, Tobias Schwarz, Henner Morbach, Angela Rösen-Wolff, Dirk Foell, Guenther Dannecker, Carsten Schepp, Gerd Ganser, Nora Honke, Thomas Eggermann, Jan Müller-Berghaus, Norbert Wagner, Kim Ohl, Klaus Tenbrock
URN:urn:nbn:de:bvb:20-opus-136281
Document Type:Journal article
Faculties:Medizinische Fakultät / Kinderklinik und Poliklinik
Language:English
Parent Title (English):Pediatric Rheumatology
Year of Completion:2015
Volume:13
Issue:61
Source:Pediatric Rheumatology (2015) 13:61. DOI 10.1186/s12969-015-0059-z
DOI:https://doi.org/10.1186/s12969-015-0059-z
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 618 Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie
Tag:IL-12B; IL-12p40; IL12B; cells; children; cytokine; gene; juvenile idiopathic arthritis; polymorphism; promoter; serum
Release Date:2016/08/24
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung