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FoxP3+Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies

Please always quote using this URN: urn:nbn:de:bvb:20-opus-115239
  • Inflammatory neuropathies represent disabling human autoimmune disorders with considerable disease variability. Animal models provide insights into defined aspects of their disease pathogenesis. Forkhead box P3 (FoxP3)+ regulatory T lymphocytes (Treg) are anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety of immune-mediated disorders. Dysfunction or a reduced frequency of Tregs have been associated with different human autoimmune disorders. We here analyzed the functional relevance of Tregs inInflammatory neuropathies represent disabling human autoimmune disorders with considerable disease variability. Animal models provide insights into defined aspects of their disease pathogenesis. Forkhead box P3 (FoxP3)+ regulatory T lymphocytes (Treg) are anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety of immune-mediated disorders. Dysfunction or a reduced frequency of Tregs have been associated with different human autoimmune disorders. We here analyzed the functional relevance of Tregs in determining disease manifestation and severity in murine models of autoimmune neuropathies. We took advantage of the DEREG mouse system allowing depletion of Treg with high specificity as well as anti-CD25 directed antibodies to deplete Tregs in mice in actively induced experimental autoimmune neuritis (EAN). Furthermore antibody-depletion was performed in an adoptive transfer model of chronic neuritis. Early Treg depletion increased clinical EAN severity both in active and adoptive transfer chronic neuritis. This was accompanied by increased proliferation of myelin specific T cells and histological signs of peripheral nerve inflammation. Late stage Treg depletion after initial disease manifestation however did not exacerbate inflammatory neuropathy symptoms further. We conclude that Tregs determine disease severity in experimental autoimmune neuropathies during the initial priming phase, but have no major disease modifying function after disease manifestation. Potential future therapeutic approaches targeting Tregs should thus be performed early in inflammatory neuropathies.show moreshow less

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Metadaten
Author: Gerd Meyer zu Hörste, Steffen Cordes, Anne K. Mausberg, Alla L. Zozulya, Carsten Wessig, Tim Sparwasser, Christian Mathys, Heinz Wiendl, Hans-Peter Hartung, Bernd C. Kieseier
URN:urn:nbn:de:bvb:20-opus-115239
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):PLOS ONE
Year of Completion:2014
Volume:9
Issue:10
Pagenumber:e108756
Source:PLoS ONE 9(10): e108756. doi:10.1371/journal.pone.0108756
DOI:https://doi.org/10.1371/journal.pone.0108756
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:C57BL/6 mice; Guillain-Barre-Syndrome; cytokines; demyelinating polyradiculoneuropathy; enteropathy; experimental autoimmune neuritis; pathogenesis; peptide; polyneuropathy; regulatory cells
Release Date:2015/07/11
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung