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Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer

Please always quote using this URN: urn:nbn:de:bvb:20-opus-123990
  • Lymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were drawn. Only recently, improved survival due to completion of radical prostatectomy (RP) (compared to abandoning RP) in known or presumed lymph-node-positive patients has been shown. Lymph node sampling can only be considered representative if anLymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were drawn. Only recently, improved survival due to completion of radical prostatectomy (RP) (compared to abandoning RP) in known or presumed lymph-node-positive patients has been shown. Lymph node sampling can only be considered representative if an adequate number of nodes is removed. While several authors have suggested that a therapeutic benefit in patients undergoing RP is not provided by PLND, the reliability of these studies is uncertain. Contrary to this, several studies have indicated the possibility of long-term survival even in the presence of limited lymph node metastases. The role and timing of initiation of adjuvant androgen deprivation therapy (ADT) in patients who have node-positive disease after RP is controversial. Recent studies suggest that delaying ADT may not adversely impact survival.show moreshow less

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Metadaten
Author: Anthony Van Baelen, Nicolas Mottet, Martin Spahn, Alberto Briganti, Paolo Gontero, Steven Joniau
URN:urn:nbn:de:bvb:20-opus-123990
Document Type:Journal article
Faculties:Medizinische Fakultät / Urologische Klinik und Poliklinik
Language:English
Parent Title (English):Advances in Urology
Year of Completion:2012
Volume:2012
Issue:983058
Source:Advances in Urology. 2012; 2012: 983058. doi:10.1155/2012/983058
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:Prostatakrebs
Release Date:2016/01/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung