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Hebbian Plasticity Guides Maturation of Glutamate Receptor Fields In Vivo

Please always quote using this URN: urn:nbn:de:bvb:20-opus-128804
  • Synaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, we investigated synaptic plasticitySynaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, we investigated synaptic plasticity at the glutamatergic Drosophila neuromuscular junction. Remarkably, correlated pre- and postsynaptic stimulation increased postsynaptic sensitivity by promoting synapse- specific recruitment of GluR-IIA-type glutamate receptor subunits into postsynaptic receptor fields. Conversely, GluR-IIA was rapidly removed from synapses whose activity failed to evoke substantial postsynaptic depolarization. Uniting these results with developmental GluR-IIA dynamics provides a comprehensive physiological concept of how Hebbian plasticity guides synaptic maturation and sparse transmitter release controls the stabilization of the molecular composition of individual synapses.show moreshow less

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Metadaten
Author: Dmitrij Ljaschenko, Nadine Ehmann, Robert J. Kittel
URN:urn:nbn:de:bvb:20-opus-128804
Document Type:Journal article
Faculties:Medizinische Fakultät / Physiologisches Institut
Language:English
Parent Title (English):Cell Reports
Year of Completion:2013
Volume:3
Issue:5
Pagenumber:1407-1413
Source:Cell Reports 3, 1407–1413. doi:10.1016/j.celrep.2013.04.003
DOI:https://doi.org/10.1016/j.celrep.2013.04.003
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Release Date:2016/04/05
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung