Hebbian Plasticity Guides Maturation of Glutamate Receptor Fields In Vivo
Please always quote using this URN: urn:nbn:de:bvb:20-opus-128804
- Synaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, we investigated synaptic plasticitySynaptic plasticity shapes the development of functional neural circuits and provides a basis for cellular models of learning and memory. Hebbian plasticity describes an activity-dependent change in synaptic strength that is input-specific and depends on correlated pre- and postsynaptic activity. Although it is recognized that synaptic activity and synapse development are intimately linked, our mechanistic understanding of the coupling is far from complete. Using Channelrhodopsin-2 to evoke activity in vivo, we investigated synaptic plasticity at the glutamatergic Drosophila neuromuscular junction. Remarkably, correlated pre- and postsynaptic stimulation increased postsynaptic sensitivity by promoting synapse- specific recruitment of GluR-IIA-type glutamate receptor subunits into postsynaptic receptor fields. Conversely, GluR-IIA was rapidly removed from synapses whose activity failed to evoke substantial postsynaptic depolarization. Uniting these results with developmental GluR-IIA dynamics provides a comprehensive physiological concept of how Hebbian plasticity guides synaptic maturation and sparse transmitter release controls the stabilization of the molecular composition of individual synapses.…
Author: | Dmitrij Ljaschenko, Nadine Ehmann, Robert J. Kittel |
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URN: | urn:nbn:de:bvb:20-opus-128804 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Physiologisches Institut |
Language: | English |
Parent Title (English): | Cell Reports |
Year of Completion: | 2013 |
Volume: | 3 |
Issue: | 5 |
Pagenumber: | 1407-1413 |
Source: | Cell Reports 3, 1407–1413. doi:10.1016/j.celrep.2013.04.003 |
DOI: | https://doi.org/10.1016/j.celrep.2013.04.003 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Release Date: | 2016/04/05 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |