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Anti-apoptotic signature in thymic squamous cell carcinomas – functional relevance of anti-apoptotic BIRC3 expression in the thymic carcinoma cell line 1889c

Please always quote using this URN: urn:nbn:de:bvb:20-opus-132214
  • The molecular pathogenesis of thymomas and thymic arcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited sequencing efforts revealed that a broad spectrum of genes that play key roles in various common cancers are rarely affected in thymomas and TCs, suggesting that other oncogenic principles might be important.This made us re-analyze historic expression dataThe molecular pathogenesis of thymomas and thymic arcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited sequencing efforts revealed that a broad spectrum of genes that play key roles in various common cancers are rarely affected in thymomas and TCs, suggesting that other oncogenic principles might be important.This made us re-analyze historic expression data obtained in a spectrumof thymomas and thymic squamous cell carcinomas (TSCCs) with a custom-made cDNA microarray. By cluster analysis, different anti-apoptotic signatures were detected in type B3 thymoma and TSCC, including overexpression of BIRC3 in TSCCs. This was confirmed by qRT-PCR in the original and an independent validation set of tumors. In contrast to several other cancer cell lines, the BIRC3-positive TSCC cell line, 1889c showed spontaneous apoptosis after BIRC3 knock-down. Targeting apoptosis genes is worth testing as therapeutic principle in TSCC.show moreshow less

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Metadaten
Author: Bei Huang, Djeda Belharazem, Li Li, Susanne Kneitz, Philipp A. Schnabel, Ralf J. Rieker, Daniel Körner, Wilfried Nix, Berthold Schalke, Hans Konrad Müller-Hermelink, German Ott, Andreas Rosenwald, Philipp Ströbel, Alexander Marx
URN:urn:nbn:de:bvb:20-opus-132214
Document Type:Journal article
Faculties:Medizinische Fakultät / Pathologisches Institut
Language:English
Parent Title (English):Frontiers in Oncology
Year of Completion:2013
Volume:3
Issue:316
Source:Frontiers in Oncology 3:316. doi: 10.3389/fonc.2013.00316
DOI:https://doi.org/10.3389/fonc.2013.00316
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:MTCH2; apoptosis; gene expression; myasthenia gravis; targeted; thymic carcinoma; thymoma; thymus
Release Date:2016/06/07
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung