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Ileal interposition in rats with experimental type 2 like diabetes improves glycemic control independently of glucose absorption

Please always quote using this URN: urn:nbn:de:bvb:20-opus-149166
  • Bariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed. In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed. Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments. Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage. After DJB also downregulation ofBariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed. In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed. Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments. Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage. After DJB also downregulation of Na\(^{+}\)-D-glucose cotransporter SGLT1 was observed. This suggested a direct contribution of decreased glucose absorption to the antidiabetic effect of bariatric surgery. To investigate whether glucose absorption is also decreased after IIP, we induced diabetes with decreased glucose tolerance and insulin sensitivity in male rats and investigated effects of IIP on diabetes and SGLT1. After IIP, we observed weight-independent improvement of glucose tolerance, increased insulin sensitivity, and increased plasma GLP-1 after glucose gavage. The interposed ileum was increased in diameter and showed increased length of villi, hyperplasia of the epithelial layer, and increased number of L-cells. The amount of SGLT1-mediated glucose uptake in interposed ileum was increased 2-fold reaching the same level as in jejunum. Thus, improvement of glycemic control by bariatric surgery does not require decreased glucose absorption.show moreshow less

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Metadaten
Author: Christian Ferdinand Jurowich, Christoph Otto, Prashanth Reddy Rikkala, Nicole Wagner, Ivana Vrhovac, Ivan Sabolić, Christoph-Thomas Germer, Hermann Koepsell
URN:urn:nbn:de:bvb:20-opus-149166
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Medizinische Fakultät / Institut für Anatomie und Zellbiologie
Fakultät für Biologie / Julius-von-Sachs-Institut für Biowissenschaften
Language:English
Parent Title (English):Journal of Diabetes Research
Year of Completion:2015
Volume:2015
Issue:490365
Source:Journal of Diabetes Research Volume 2015, Article ID 490365 (2015). DOI: 10.1155/2015/490365
DOI:https://doi.org/10.1155/2015/490365
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Y-gastric bypass; bariatric surgery; biliopancreatic diversion; body weight; cotransporter SGLT1; duodenal jejunal bypass; food intake; glucagon like peptide-1; gut hormones; intestinal glucose
Release Date:2018/11/27
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung