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microRNAs in nociceptive circuits as predictors of future clinical applications

Please always quote using this URN: urn:nbn:de:bvb:20-opus-154597
  • Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs – and microRNAs (miRNAs) in particular – regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted functionNeuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs – and microRNAs (miRNAs) in particular – regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. Furthermore, predisposing miRNA expression patterns and inter-individual variations and polymorphisms in miRNAs and/or their binding sites may serve as biomarkers for pain and help to predict individual risks for certain types of pain and responsiveness to analgesic drugs. miRNA-based diagnostics are expected to develop into hands-on tools that allow better patient stratification, improved mechanism-based treatment, and targeted prevention strategies for high risk individuals.show moreshow less

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Author: Michaela Kress, Alexander Hüttenhofer, Marc Landry, Rohini Kuner, Alexandre Favereaux, David Greenberg, Josef Bednarik, Paul Heppenstall, Florian Kronenberg, Marzia Malcangio, Heike Rittner, Nurcan Üçeyler, Zlatko Trajanoski, Peter Mouritzen, Frank Birklein, Claudia Sommer, Hermona Soreq
URN:urn:nbn:de:bvb:20-opus-154597
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):Frontiers in Molecular Neuroscience
Year of Completion:2013
Volume:6
Issue:33
Source:Frontiers in Molecular Neuroscience 6, 33 (2013). DOI: 10.3389/fnmol.2013.00033
DOI:https://doi.org/10.3389/fnmol.2013.00033
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:antagomir; biomarker; chronic pain; miRNA expression patterns; miRNA polymorphisms; miRNA-based analgesic; miRNA-based diagnostics; polymorphism
Release Date:2017/11/07
EU-Project number / Contract (GA) number:602133
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung