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Heart Failure in a Cohort of Patients with Chronic Kidney Disease: The GCKD Study

Please always quote using this URN: urn:nbn:de:bvb:20-opus-143315
  • Background and Aims Chronic kidney disease (CKD) is a risk factor for development and progression of heart failure (HF). CKD and HF share common risk factors, but few data exist on the prevalence, signs and symptoms as well as correlates of HF in populations with CKD of moderate severity. We therefore aimed to examine the prevalence and correlates of HF in the German Chronic Kidney Disease (GCKD) study, a large observational prospective study. Methods and Results We analyzed data from 5,015 GCKD patients aged 18-74 years with anBackground and Aims Chronic kidney disease (CKD) is a risk factor for development and progression of heart failure (HF). CKD and HF share common risk factors, but few data exist on the prevalence, signs and symptoms as well as correlates of HF in populations with CKD of moderate severity. We therefore aimed to examine the prevalence and correlates of HF in the German Chronic Kidney Disease (GCKD) study, a large observational prospective study. Methods and Results We analyzed data from 5,015 GCKD patients aged 18-74 years with an estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73m\(^{2}\) or with an eGFR >= 60 and overt proteinuria (>500 mg/d). We evaluated a definition of HF based on the Gothenburg score, a clinical HF score used in epidemiological studies (Gothenburg HF), and self-reported HF. Factors associated with HF were identified using multivariable adjusted logistic regression. The prevalence of Gothenburg HF was 43% (ranging from 24% in those with eGFR >90 to 59% in those with eGFR<30 ml/min/1.73m2). The corresponding estimate for self-reported HF was 18% (range 5%-24%). Lower eGFR was significantly and independently associated with the Gothenburg definition of HF (p-trend <0.001). Additional significantly associated correlates included older age, female gender, higher BMI, hypertension, diabetes mellitus, valvular heart disease, anemia, sleep apnea, and lower educational status. Conclusions The burden of self-reported and Gothenburg HF among patients with CKD is high. The proportion of patients who meet the criteria for Gothenburg HF in a European cohort of patients with moderate CKD is more than twice as high as the prevalence of self-reported HF. However, because of the shared signs, symptoms and medications of HF and CKD, the Gothenburg score cannot be used to reliably define HF in CKD patients. Our results emphasize the need for early screening for HF in patients with CKD.show moreshow less

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Metadaten
Author: Hanna Beck, Stephanie I. Titze, Silvia Hübner, Martin Busch, Georg Schlieper, Ulla T. Schultheiss, Christoph Wanner, Florian Kronenberg, Vera Krane, Kai-Uwe Eckardt, Anna Köttgen
URN:urn:nbn:de:bvb:20-opus-143315
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik I
Language:English
Parent Title (English):PLoS ONE
Year of Completion:2015
Volume:10
Issue:4
Pagenumber:e0122552
Source:PLoS ONE 10(4): e0122552 (2015). DOI: 10.1371/journal.pone.0122552
DOI:https://doi.org/10.1371/journal.pone.0122552
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:European Society; KDIGO; United States; atherosclerosis risk; cardiovascularm disease; consensus conference; epidemiology; global outcomes; glomerular filtration rate; insufficiency; men born
Release Date:2017/11/09
Contributing Corporation:GCKD Investigators
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International