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Ultra-high to ultra-low drug loaded micelles: Probing host-guest interactions by fluorescence spectroscopy

Please always quote using this URN: urn:nbn:de:bvb:20-opus-206128
  • Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug‐loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra‐high curcumin loading exceeding 50 wt.%, while the other allows a drug loading of only 25 wt.%. In the lowPolymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug‐loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra‐high curcumin loading exceeding 50 wt.%, while the other allows a drug loading of only 25 wt.%. In the low capacity micelles, steady‐state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510 nm. Time‐resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high‐capacity micelles, preventing an observable emission in steady‐state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles.show moreshow less

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Metadaten
Author: Michael M. Lübtow, Henning Marciniak, Alexander Schmiedel, Markus Roos, Christoph Lambert, Robert Luxenhofer
URN:urn:nbn:de:bvb:20-opus-206128
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Organische Chemie
Fakultät für Chemie und Pharmazie / Lehrstuhl für Chemische Technologie der Materialsynthese
Language:English
Parent Title (English):Chemistry - A European Journal
Year of Completion:2019
Volume:25
Issue:54
Pagenumber:12601-12610
Source:Chemistry - A European Journal (2019) 25:54, 12601-12610. https://doi.org/10.1002/chem.201902619
DOI:https://doi.org/10.1002/chem.201902619
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
GND Keyword:Polymer-drug interaction; upconversion
Tag:curcumin; drug delivery; fluorenscence; pol(2-oxazoline); poly(2-oxazine)
Release Date:2020/06/30
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International