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Novel functional renal PET imaging with 18F-FDS in human subjects

Please always quote using this URN: urn:nbn:de:bvb:20-opus-174634
  • The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thoroughThe novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.show moreshow less

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Metadaten
Author: Rudolf A. Werner, Alvaro A. Ordonez, Julian Sanchez-Bautista, Charles Marcus, Constantin Lapa, Steven P. Rowe, Martin G. Pomper, Jeffrey P. Leal, Martin A. Lodge, Mehrbod S. Javadi, Sanjay K. Jain, Takahiro Higuchi
URN:urn:nbn:de:bvb:20-opus-174634
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin
Language:English
Parent Title (English):Clinical Nuclear Medicine
ISSN:0363-9762
Year of Completion:2019
Volume:44
Issue:5
Pagenumber:410-411
Source:Clinical Nuclear Medicine (2019) 44, 5, p. 410-411. doi: 10.1097/RLU.0000000000002494
Sonstige beteiligte Institutionen:Johns Hopkins School of Medicine
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Positronen-Emissions-Tomografie
Tag:18F-FDS; 2-deoxy-2-18F-fluoro-D-sorbitol; Positron-Emission Tomography; kidney; renal imaging; split renal function
Release Date:2019/06/04
EU-Project number / Contract (GA) number:701983
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International