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Individual Constituents from Essential Oils Inhibit Biofilm Mass Production by Multi-Drug Resistant Staphylococcus aureus

Please always quote using this URN: urn:nbn:de:bvb:20-opus-151845
  • Biofilm formation by Staphylococcus aureus represents a problem in both the medical field and the food industry, because the biofilm structure provides protection to embedded cells and it strongly attaches to surfaces. This circumstance is leading to many research programs seeking new alternatives to control biofilm formation by this pathogen. In this study we show that a potent inhibition of biofilm mass production can be achieved in community-associated methicillin-resistant S. aureus (CA-MRSA) and methicillin-sensitive strains using plantBiofilm formation by Staphylococcus aureus represents a problem in both the medical field and the food industry, because the biofilm structure provides protection to embedded cells and it strongly attaches to surfaces. This circumstance is leading to many research programs seeking new alternatives to control biofilm formation by this pathogen. In this study we show that a potent inhibition of biofilm mass production can be achieved in community-associated methicillin-resistant S. aureus (CA-MRSA) and methicillin-sensitive strains using plant compounds, such as individual constituents (ICs) of essential oils (carvacrol, citral, and (+)-limonene). The Crystal Violet staining technique was used to evaluate biofilm mass formation during 40 h of incubation. Carvacrol is the most effective IC, abrogating biofilm formation in all strains tested, while CA-MRSA was the most sensitive phenotype to any of the ICs tested. Inhibition of planktonic cells by ICs during initial growth stages could partially explain the inhibition of biofilm formation. Overall, our results show the potential of EOs to prevent biofilm formation, especially in strains that exhibit resistance to other antimicrobials. As these compounds are food additives generally recognized as safe, their anti-biofilm properties may lead to important new applications, such as sanitizers, in the food industry or in clinical settings.show moreshow less

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Metadaten
Author: Laura Espina, Rafael Pagán, Daniel López, Diego García-Gonzalo
URN:urn:nbn:de:bvb:20-opus-151845
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Molekulare Infektionsbiologie
Language:English
Parent Title (English):Molecules
Year of Completion:2015
Volume:20
First Page:11357
Last Page:11372
Source:Molecules 20, 11357-11372 (2015). DOI: 10.3390/molecules200611357
DOI:https://doi.org/10.3390/molecules200611357
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:(+)-limonene; Listeria monocytogenes; Staphylococcus aureus; anti-biofilm; antibacterial; bacterial biofilms; biofilms; carvacrol; citral; citrus; components; essential oils; food industry; inactivation; strains
Release Date:2017/10/27
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International