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Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma

Please always quote using this URN: urn:nbn:de:bvb:20-opus-132184
  • The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system - partly conferred by catechol-O-methyltransferase (COMT) gene variation - for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of theThe etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system - partly conferred by catechol-O-methyltransferase (COMT) gene variation - for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design) and childhood maltreatment (CTQ) as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.show moreshow less

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Metadaten
Author: Benedikt Klauke, Bernward Winter, Agnes Gajewska, Peter Zwanzger, Andreas Reif, Martin J. Herrmann, Andrea Dlugos, Bodo Warrings, Christian Jacob, Andreas Mühlberger, Volker Arolt, Paul Pauli, Jürgen Deckert, Katharina Domschke
URN:urn:nbn:de:bvb:20-opus-132184
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Fakultät für Humanwissenschaften (Philos., Psycho., Erziehungs- u. Gesell.-Wissensch.) / Institut für Psychologie
Language:English
Parent Title (English):PLoS One
Year of Completion:2012
Volume:7
Issue:6
Pagenumber:e39709
Source:PLoS ONE 7(6): e39709. doi:10.1371/journal.pone.0039709
DOI:https://doi.org/10.1371/journal.pone.0039709
Dewey Decimal Classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
Tag:COMT VAL(158)MET polymorphism; acoustic startle; caffeine-induced anxiety; community sample; fear-potentiated startle; life events; panic disorder; posttraumatic-stress-disorder; prepulse inhibition; serotonin transporter gene
Release Date:2017/01/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung