The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 4 of 42
Back to Result List

Progressive encephalopathy and myopathy in transgenic mice expressing human foamy virus genes

Please always quote using this URN: urn:nbn:de:bvb:20-opus-61453
  • Transgenie mice carrying the bel region of human foamy retrovirus (HFV) under transcriptional control of its own long terminal repeat expressed tbe transgene in their centrat nervous systems and in smootb and striated muscle tissues. The animals developed a progressive degenerative disease of tbe centrat nervous system and of the striated muscle. Because expression of tbe transgene was dosely correlated witb the appearance of structural damage and inflammatory reactions were scanty, the disease is likely to be caused directly by tbe HFVTransgenie mice carrying the bel region of human foamy retrovirus (HFV) under transcriptional control of its own long terminal repeat expressed tbe transgene in their centrat nervous systems and in smootb and striated muscle tissues. The animals developed a progressive degenerative disease of tbe centrat nervous system and of the striated muscle. Because expression of tbe transgene was dosely correlated witb the appearance of structural damage and inflammatory reactions were scanty, the disease is likely to be caused directly by tbe HFV proteins. These unexpected findings call for a reevaluation of tbe patbogenic potential of HFV in humans.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Katrin Bothe, Adriano Aguzzi, Hans Lassmann, Axel Rethwilm, Ivan Horak
URN:urn:nbn:de:bvb:20-opus-61453
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Language:English
Year of Completion:1991
Source:In: Science (1991) 25, 5019, 555-557
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Virologie
Release Date:2011/09/17
Licence (German):License LogoDeutsches Urheberrecht