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Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease

Please always quote using this URN: urn:nbn:de:bvb:20-opus-119351
  • We investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[(123)I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([(123)I]5IA). Patients were selected according to several criteria, including short duration of motor signs (<7 years) and normal scores at an extensive neuropsychological evaluation. In PDWe investigated in vivo brain nicotinic acetylcholine receptor (nAChR) distribution in cognitively intact subjects with Parkinson's disease (PD) at an early stage of the disease. Fourteen patients and 13 healthy subjects were imaged with single photon emission computed tomography and the radiotracer 5-[(123)I]iodo-3-[2(S)-2-azetidinylmethoxy]pyridine ([(123)I]5IA). Patients were selected according to several criteria, including short duration of motor signs (<7 years) and normal scores at an extensive neuropsychological evaluation. In PD patients, nAChR density was significantly higher in the putamen, the insular cortex and the supplementary motor area and lower in the caudate nucleus, the orbitofrontal cortex, and the middle temporal gyrus. Disease duration positively correlated with nAChR density in the putamen ipsilateral (ρ = 0.56, p < 0.05) but not contralateral (ρ = 0.49, p = 0.07) to the clinically most affected hemibody. We observed, for the first time in vivo, higher nAChR density in brain regions of the motor and limbic basal ganglia circuits of subjects with PD. Our findings support the notion of an up-regulated cholinergic activity at the striatal and possibly cortical level in cognitively intact PD patients at an early stage of disease.show moreshow less

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Metadaten
Author: Ioannis Ugo Isaias, Jörg Spiegel, Joachim Brumberg, Kelly P. Cosgrove, Giorgio Marotta, Naoya Oishi, Takahiro Higuchi, Sebastian Küsters, Markus Schiller, Ulrich Dillmann, Christopher H. van Dyck, Andreas Buck, Ken Herrmann, Susanne Schloegl, Jens Volkmann, Michael Lassmann, Klaus Fassbender, Reinhard Lorenz, Samuel Samnick
URN:urn:nbn:de:bvb:20-opus-119351
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin
Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Parent Title (English):Frontiers in Aging Neuroscience
Year of Completion:2014
Volume:6
Pagenumber:213
Source:Frontiers in Aging Neuroscience 6:213. doi: 10.3389/fnagi.2014.00213
DOI:https://doi.org/10.3389/fnagi.2014.00213
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25177294
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten
Tag:5IA-SPECT; Parkinson disease; cognitive decline; dopamine acetylcholine; nicotinic receptors
Release Date:2015/10/21
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung