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Human Tuberculous Meningitis Caused by \(Mycobacterium\) \(caprae\)
Please always quote using this URN: urn:nbn:de:bvb:20-opus-123425
- INTRODUCTION: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis. CASE PRESENTATION: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC byINTRODUCTION: Tuberculous meningitis (TM) causes substantial morbidity and mortality in humans. Human TM has been known to be induced by bacteria from the Mycobacterium tuberculosis complex (MTBC), such as M. tuberculosis and M. bovis. CASE PRESENTATION: We describe a case of meningitis treated with fosfomycin, which showed partial effectiveness in an 80-year-old patient. After a lethal myocardial infarction, M. caprae (MC) was identified in cerebrospinal fluid culture. This isolated acid-fast organism was first identified as MTBC by MTBC-specific PCR (16S rDNA-PCR). Furthermore, species-specific identification of the isolate was done by gyrB PCR-restriction fragment length polymorphism analysis of a part of gyrB DNA. Colony morphology of the isolated MC strain showed dysgonic growth on Lowenstein-Jensen medium. The strain was susceptible to pyrazinamide (PZA). CONCLUSION: This isolated strain was convincingly identified as MC according to the phenotypic and genotypic characteristics and PZA sensitivity. This is the first report of MC causing TM.…
Author: | Niels Hansen, Carola Seiler, Julian Rumpf, Peter Kraft, Henry Dlaske, Marianne Abele-Horn, Wolfgang Muellges |
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URN: | urn:nbn:de:bvb:20-opus-123425 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Language: | English |
Parent Title (English): | Case Reports in Neurology |
Year of Completion: | 2012 |
Volume: | 4 |
Issue: | 1 |
Pagenumber: | 54-60 |
Source: | Case Reports in Neurology. 4(1):54-60. DOI:10.1159/000337299 |
DOI: | https://doi.org/10.1159/000337299 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/PMC3335363 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Tag: | Mycobacterium caprae; Tuberkulose Mycobacterium caprae; Mycobacterium tuberculosis complex; cerebrospinal fluid culture; fosfomycin; tuberculous meningitis |
Release Date: | 2015/12/21 |
Licence (German): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitung |