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Assessment of damage from implantation of microdialysis probes in the rat hippocampus with silver degeneration staining

Please always quote using this URN: urn:nbn:de:bvb:20-opus-47433
  • We used a sensitive silver degeneration staining method to study the effects of insertion of microdialysis probes in rat dorsal hippocampus and neocortex. Nine animals were sacrificed 24 h, 3 days or 7 days after implantation of dialysis tubing. Although mild neuronal cell death and small petechial hemorrhages were seen in elose proximity to the implantation site, the striking finding was the presence of degenerating axons both adjacent to the implantation site and in remote sites such as the corpus callosum and contralateral hippocampus. TheWe used a sensitive silver degeneration staining method to study the effects of insertion of microdialysis probes in rat dorsal hippocampus and neocortex. Nine animals were sacrificed 24 h, 3 days or 7 days after implantation of dialysis tubing. Although mild neuronal cell death and small petechial hemorrhages were seen in elose proximity to the implantation site, the striking finding was the presence of degenerating axons both adjacent to the implantation site and in remote sites such as the corpus callosum and contralateral hippocampus. The observed changes could alter brain function near or remote from the implantation site and should be considered in analysis of dialysis experiments.show moreshow less

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Metadaten
Author: A. Shuaib, K. Xu, B. Crain, Anna-Leena Sirén, Giora Feuerstein, J. Hallenbeck, JN Davis
URN:urn:nbn:de:bvb:20-opus-47433
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik
Language:English
Year of Completion:1990
Source:In: Neuroscience Letters (1990) 112, 149-154.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Neurophysiologie; Neurobiologie
Tag:Axonal degeneration; In-vivo dia lysis; Rat hippocampus; Silver degeneration staining
Release Date:2011/01/12
Licence (German):License LogoDeutsches Urheberrecht