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Respiratory \(\mu\)-Opioid and benzodiazepine interactions in the understrained rat

Please always quote using this URN: urn:nbn:de:bvb:20-opus-62974
  • lnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolamlnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolam potentiateri the respiratory inhibition of a small (I nmol) dose of dermorphin but antagonized that of a higher dos:~ (3 nmol). The results suggest that the benzodiazepine/GABA receptor complex modulates respiratory depression induced by centrat p-receptor Stimulation in the rat.show moreshow less

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Metadaten
Author: P. Paakkari, I. Paakkari, P. Landes, Anna-Leena Sirén, G. Feuerstein
URN:urn:nbn:de:bvb:20-opus-62974
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik
Language:English
Year of Completion:1993
Source:In: Neuropharmacology (1993) 32, 323-329.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Neurobiologie
Tag:benzodiazepine antagonist.; dermorphin; flumazenil; opioid receptors; opioid-benzodiazepine interactions; respiration
Release Date:2012/07/26
Licence (German):License LogoDeutsches Urheberrecht