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Protective effect of PAF-acether antagonist, BN 52021, in trichothecen toxicosis

Please always quote using this URN: urn:nbn:de:bvb:20-opus-63244
  • Trichothecenes are mycotoxins which produce Iethai toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly Iethai T -2 toxicosis. These data also suggest that P AF is an important mediator of this unique toxicosis.

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Metadaten
Author: G. Feuerstein, P. Leader, Anna-Leena Sirén, P. Braquet
URN:urn:nbn:de:bvb:20-opus-63244
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik
Language:English
Year of Completion:1987
Source:In: Toxicology letters (1987) 38, 271-274.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Neurobiologie
Tag:BN 52021; PAF-acether; T-2 toxin; mycotoxin; rat
Release Date:2012/08/07
Licence (German):License LogoDeutsches Urheberrecht