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An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice

Please always quote using this URN: urn:nbn:de:bvb:20-opus-75368
  • Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.show moreshow less

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Metadaten
Author: Christiane Albert-Weißenberger, Csanád Várrallyay, Furat Raslan, Christoph Kleinschnitz, Anna-Leena Sirén
URN:urn:nbn:de:bvb:20-opus-75368
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurologische Klinik und Poliklinik
Language:English
Year of Completion:2012
Source:In: Experimental & Translational Stroke Medicine (2012) 4: 1, doi:10.1186/2040-7378-4-1
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Medizin
Tag:astrocyte; closed head injury; microglia; neurobehavioural deficits; neurons; traumatic brain injury
Release Date:2013/03/25
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2012
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung