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Oncolytic Virotherapy of Canine and Feline Cancer

Please always quote using this URN: urn:nbn:de:bvb:20-opus-119753
  • Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes theCancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and lyse cancer cells, without causing excessive damage to surrounding healthy tissue, and initiate tumor-specific immunity. The current review describes the use of different oncolytic viruses for cancer therapy and their application to canine and feline cancer.show moreshow less

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Metadaten
Author: Ivaylo Gentschev, Sadeep S. Patil, Ivan Petrov, Joseph Cappello, Marion Adelfinger, Aladar A. Szalay
URN:urn:nbn:de:bvb:20-opus-119753
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Lehrstuhl für Biochemie
Language:English
Parent Title (English):Viruses
Year of Completion:2014
Volume:6
Issue:5
Pagenumber:2122-2137
Source:Viruses 2014, 6, 2122-2137; doi:10.3390/v6052122
DOI:https://doi.org/10.3390/v6052122
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:cancer; canine and feline cancer therapy; oncolysis; oncolytic virus
Release Date:2015/11/12
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung