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Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

Please always quote using this URN: urn:nbn:de:bvb:20-opus-144275
  • Models of the outer epithelia of the human body namely the skin, the intestine and the lung have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts inModels of the outer epithelia of the human body namely the skin, the intestine and the lung have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model these barriers are currently employed in such fields, ranging from the utilization of ex vivo tissue to reconstructed in vitro models, and further to chip-based technologies, synthetic membrane systems and, of increasing current interest, in silico modeling approaches. An international group of experts in the field of epithelial barriers was convened from academia, industry and regulatory bodies to present both the current state of the art of non-animal models of the skin, intestinal and pulmonary barriers in their various fields of application, and to discuss research-based, industry-driven and regulatory-relevant future directions for both the development of new models and the refinement of existing test methods. Issues of model relevance and preference, validation and standardization, acceptance, and the need for simplicity versus complexity were focal themes of the discussions. The outcomes of workshop presentations and discussions, in relation to both current status and future directions in the utilization and development of epithelial barrier models, are presented by the attending experts in the current report.show moreshow less

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Author: Sarah Gordon, Mardas Daneshian, Joke Bouwstra, Francesca Caloni, Samuel Constant, Donna E. Davies, Gudrun Dandekar, Carlos A. Guzman, Eric Fabian, Eleonore Haltner, Thomas Hartung, Nina Hasiwa, Patrick Hayden, Helena Kandarova, Sangeeta Khare, Harald F. Krug, Carsten Kneuer, Marcel Leist, Guoping Lian, Uwe Marx, Marco Metzger, Katharina Ott, Pilar Prieto, Michael S. Roberts, Erwin L. Roggen, Tewes Tralau, Claudia van den Braak, Heike Walles, Claus-Michael Lehr
URN:urn:nbn:de:bvb:20-opus-144275
Document Type:Journal article
Faculties:Medizinische Fakultät / Lehrstuhl für Tissue Engineering und Regenerative Medizin
Language:English
Parent Title (English):ALTEX: Alternatives to Animal Experimentation
Year of Completion:2015
Volume:32
Issue:4
Pagenumber:327-378
Source:ALTEX 32(4), 2015, 327-378. DOI: 10.14573/altex.1510051
DOI:https://doi.org/10.14573/altex.1510051
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:air-liquid interface; artificial membrane-permeability; asthmatic bronchial epithelium; cytotoxicity; embryonic stem cells; epithelial cell culture; in vitro models; on-a-chip; permeability; pulmonary drug-delivery; reconstructed human epidermis; respiratory syncytial virus; transport studies; vesicle-based barrier
Release Date:2019/01/28
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International