• search hit 2 of 3
Back to Result List

MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy

Please always quote using this URN: urn:nbn:de:bvb:20-opus-164422
  • Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of successful fear extinction, the present psychotherapy-epigenetic study for we believe the first time investigated MAOA methylation changes during the course of exposure-based cognitive behavioral therapy (CBT) in PD. MAOA methylation was compared between N=28 female Caucasian PD patients (discovery sample) and N=28 age- and sex-matchedEpigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of successful fear extinction, the present psychotherapy-epigenetic study for we believe the first time investigated MAOA methylation changes during the course of exposure-based cognitive behavioral therapy (CBT) in PD. MAOA methylation was compared between N=28 female Caucasian PD patients (discovery sample) and N=28 age- and sex-matched healthy controls via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells. MAOA methylation was furthermore analyzed at baseline (T0) and after a 6-week CBT (T1) in the discovery sample parallelized by a waiting time in healthy controls, as well as in an independent sample of female PD patients (N=20). Patients exhibited lower MAOA methylation than healthy controls (P<0.001), and baseline PD severity correlated negatively with MAOA methylation (P=0.01). In the discovery sample, MAOA methylation increased up to the level of healthy controls along with CBT response (number of panic attacks; T0-T1: +3.37±2.17%), while non-responders further decreased in methylation (-2.00±1.28%; P=0.001). In the replication sample, increases in MAOA methylation correlated with agoraphobic symptom reduction after CBT (P=0.02-0.03). The present results support previous evidence for MAOA hypomethylation as a PD risk marker and suggest reversibility of MAOA hypomethylation as a potential epigenetic correlate of response to CBT. The emerging notion of epigenetic signatures as a mechanism of action of psychotherapeutic interventions may promote epigenetic patterns as biomarkers of lasting extinction effects.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: C. Ziegler, J. Richter, M. Mahr, A. Gajewska, M.A. Schiele, A. Gehrmann, B. Schmidt, K.-P. Lesch, T. Lang, S. Helbig-Lang, P. Pauli, T. Kircher, A. Reif, W. Rief, A.N. Vossbeck-Elsebusch, V. Arolt, H.-U. Wittchen, A.O. Hamm, J. Deckert, K. Domschke
URN:urn:nbn:de:bvb:20-opus-164422
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Psychotherapie und Medizinische Psychologie
Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Language:English
Parent Title (English):Translational Psychiatry
Year of Completion:2016
Issue:6
Pagenumber:e773
Source:Transl Psychiatry (2016) 6, e773; doi:10.1038/tp.2016.41
DOI:https://doi.org/10.1038/tp.2016.41
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Adult; Case-Control Studies; Cognitive Therapy; DNA; DNA Methylation; Epigenesis; Female; Genetic; Humans; Monoamine Oxidase/genetics; Panic Disorder/genetics; Panic Disorder/therapy; Sequence Analysis
Release Date:2019/07/10
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International