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High convection volume in online post-dilution haemodiafiltration: relevance, safety and costs

Please always quote using this URN: urn:nbn:de:bvb:20-opus-149814
  • Increasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, theIncreasing evidence suggests that treatment with online post-dilution haemodiafiltration (HDF) improves clinical outcome in patients with end-stage kidney disease, if compared with haemodialysis (HD). Although the primary analyses of three large randomized controlled trials (RCTs) showed inconclusive results, post hoc analyses of these and previous observational studies comparing online post-dilution HDF with HD showed that the risk of overall and cardiovascular mortality is lowest in patients who are treated with high-volume HDF. As such, the magnitude of the convection volume seems crucial and can be considered as the ‘dose’ of HDF. In this narrative review, the relevance of high convection volume in online post-dilution HDF is discussed. In addition, we briefly touch upon some safety and cost issues.show moreshow less

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Metadaten
Author: Ira M. Mostovaya, Muriel P.C. Grooteman, Carlo Basile, Andrew Davenport, Camiel L.M. de Roij van Zuijdewijn, Christoph Wanner, Menso J. Nubé, Peter J. Blankestijn
URN:urn:nbn:de:bvb:20-opus-149814
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik I
Language:English
Parent Title (English):Clinical Kidney Journal
Year of Completion:2015
Volume:8
Issue:4
Pagenumber:368-373
Source:Clinical Kidney Journal, 2015, 8(4), 368–373. DOI: 10.1093/ckj/sfv040
DOI:https://doi.org/10.1093/ckj/sfv040
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=PMC4515895
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:convection volume; costs; hemodiafiltration; mortality; safety
Release Date:2019/01/22
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International