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Synapsin is required to "boost" memory strength for highly salient events

Please always quote using this URN: urn:nbn:de:bvb:20-opus-191440
  • Synapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the Drosophila genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function at the behavioral level. Task-relevant sensorimotor functions, however, remain intact in the absence of Synapsin. Using an odor-sugar reward associative learning paradigm in larval Drosophila, we show that memorySynapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the Drosophila genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function at the behavioral level. Task-relevant sensorimotor functions, however, remain intact in the absence of Synapsin. Using an odor-sugar reward associative learning paradigm in larval Drosophila, we show that memory scores in mutants lacking Synapsin (syn\(^{97}\)) are lower than in wild-type animals only when more salient, higher concentrations of odor or of the sugar reward are used. Furthermore, we show that Synapsin is selectively required for larval short-term memory. Thus, without Synapsin Drosophila larvae can learn and remember, but Synapsin is required to form memories that match in strength to event salience-in particular to a high saliency of odors, of rewards, or the salient recency of an event. We further show that the residual memory scores upon a lack of Synapsin are not further decreased by an additional lack of the Sap47 protein. In combination with mass spectrometry data showing an up-regulated phosphorylation of Synapsin in the larval nervous system upon a lack of Sap47, this is suggestive of a functional interdependence of Synapsin and Sap47.show moreshow less

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Metadaten
Author: Jörg Kleber, Yi-Chun Chen, Birgit Michels, Timo Saumweber, Michael Schleyer, Thilo Kähne, Erich Buchner, Bertram Gerber
URN:urn:nbn:de:bvb:20-opus-191440
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Klinische Neurobiologie
Language:English
Parent Title (English):Learning and Memory
Year of Completion:2016
Volume:23
Issue:1
Pagenumber:9-20
Source:Learning and Memory (2016) 23:1, S. 9-20. https://doi.org/10.1101/lm.039685.115
DOI:https://doi.org/10.1101/lm.039685.115
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Kenyon cells; Sap47; larval drosophila; mushroom body; phosphorylation; short-term memory; synaptic vesicles
Release Date:2021/02/26
EU-Project number / Contract (GA) number:FP7-ICT MINIMAL
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International