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Immunological Aspects of Candida and Aspergillus Systemic Fungal Infections

Please always quote using this URN: urn:nbn:de:bvb:20-opus-129327
  • Patients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells fromTLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, andPatients with allogeneic stem cell transplantation (SCT) have a high risk of invasive fungal infections (IFIs) even after neutrophil regeneration. Immunological aspects might play a very important role in the IFI development in these patients. Some data are available supporting the identification of high-risk patients with IFI for example patients receiving stem cells fromTLR4 haplotype S4 positive donors. Key defense mechanisms against IFI include the activation of neutrophils, the phagocytosis of germinating conidia by dendritic cells, and the fight of the cells of the innate immunity such as monocytes and natural killer cells against germlings and hyphae. Furthermore, immunosuppressive drugs interact with immune effector cells influencing the specific fungal immune defense and antimycotic drugs might interact with immune response. Based on the current knowledge on immunological mechanism in Aspergillus fumigatus, the first approaches of an immunotherapy using human T cells are in development. This might be an option for the future of aspergillosis patients having a poor prognosis with conventional treatment.show moreshow less

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Metadaten
Author: Christoph Mueller-Loebnitz, Helmut Ostermann, Anke Franzke, Juergen Loeffler, Lutz Uharek, Max Topp, Hermann Einsele
URN:urn:nbn:de:bvb:20-opus-129327
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik II
Language:English
Parent Title (English):Interdisciplinary Perspectives on Infectious Diseases
Year of Completion:2013
Issue:ID 102934
Source:Interdisciplinary Perspectives on Infectious Diseases, Volume 2013, Article ID 102934, 7 pages, http://dx.doi.org/10.1155/2013/102934
DOI:https://doi.org/10.1155/2013/102934
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Infectious Diseases
Release Date:2016/06/24
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung