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Efficacy of an internet-based program to promote physical activity and exercise after inpatient rehabilitation in persons with multiple sclerosis: a randomized, single-blind, controlled study
Please always quote using this URN: urn:nbn:de:bvb:20-opus-207863
- Background: Multimodal rehabilitation improves fatigue and mobility in persons with multiple sclerosis (PwMS). Effects are transient and may be conserved by internet-based physical activity promotion programs. Objective: Evaluate the effects of internet-based physical activity and exercise promotion on fatigue, quality of life, and gait in PwMS after inpatient rehabilitation. Methods: PwMS (Expanded Disability Status Scale (EDSS) ≤ 6.0, fatigue: Würzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) ≥ 32) were randomized into anBackground: Multimodal rehabilitation improves fatigue and mobility in persons with multiple sclerosis (PwMS). Effects are transient and may be conserved by internet-based physical activity promotion programs. Objective: Evaluate the effects of internet-based physical activity and exercise promotion on fatigue, quality of life, and gait in PwMS after inpatient rehabilitation. Methods: PwMS (Expanded Disability Status Scale (EDSS) ≤ 6.0, fatigue: Würzburg Fatigue Inventory for Multiple Sclerosis (WEIMuS) ≥ 32) were randomized into an intervention group (IG) or a control group (CG). After rehabilitation, IG received 3 months of internet-based physical activity promotion, while CG received no intervention. Primary outcome: self-reported fatigue (WEIMuS). Secondary outcomes: quality of life (Multiple Sclerosis Impact Scale 29, MSIS-29), gait (2min/10m walking test, Tinetti score). Measurements: beginning (T0) and end (T1) of inpatient rehabilitation, 3 (T2) and 6 (T3) months afterwards. Results: 64 of 84 PwMS were analyzed (IG: 34, CG: 30). After rehabilitation, fatigue decreased in both groups. At T2 and T3, fatigue increased again in CG but was improved in IG (p < 0.001). MSIS-29 improved in both groups at T1 but remained improved at T2 and T3 only in IG. Gait improvements were more pronounced in IG at T2. Conclusions: The study provides Class II evidence that the effects of rehabilitation on fatigue, quality of life, and gait can be maintained for 3–6 months with an internet-based physical activity and exercise promotion program.…
| Author: | Peter Flachenecker, Anna Karoline Bures, Angeli Gawlik, Ann-Christin Weiland, Sarah Kuld, Klaus Gusowski, René Streber, Klaus Pfeifer, Alexander Tallner |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-207863 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
| Language: | English |
| Parent Title (English): | International Journal of Environmental Research and Public Health |
| ISSN: | 1660-4601 |
| Year of Completion: | 2020 |
| Volume: | 17 |
| Issue: | 12 |
| Article Number: | 4544 |
| Source: | International Journal of Environmental Research and Public Health (2020) 17:12, 4544. https://doi.org/10.3390/ijerph17124544 |
| DOI: | https://doi.org/10.3390/ijerph17124544 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | exercise; fatigue; health behavior; internet-based intervention; multiple sclerosis; online systems; physical activity; quality of life; rehabilitation; walking |
| Release Date: | 2022/05/31 |
| Date of first Publication: | 2020/06/24 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |