• search hit 9 of 25
Back to Result List

The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits

Please always quote using this URN: urn:nbn:de:bvb:20-opus-132152
  • Several attributes intuitively considered to be typical mammalian features, such as complex behavior, live birth and malignant disease such as cancer, also appeared several times independently in lower vertebrates. The genetic mechanisms underlying the evolution of these elaborate traits are poorly understood. The platyfish, X. maculatus, offers a unique model to better understand the molecular biology of such traits. We report here the sequencing of the platyfish genome. Integrating genome assembly with extensive genetic maps identified anSeveral attributes intuitively considered to be typical mammalian features, such as complex behavior, live birth and malignant disease such as cancer, also appeared several times independently in lower vertebrates. The genetic mechanisms underlying the evolution of these elaborate traits are poorly understood. The platyfish, X. maculatus, offers a unique model to better understand the molecular biology of such traits. We report here the sequencing of the platyfish genome. Integrating genome assembly with extensive genetic maps identified an unexpected evolutionary stability of chromosomes in fish, in contrast to in mammals. Genes associated with viviparity show signatures of positive selection, identifying new putative functional domains and rare cases of parallel evolution. We also find that genes implicated in cognition show an unexpectedly high rate of duplicate gene retention after the teleost genome duplication event, suggesting a hypothesis for the evolution of the behavioral complexity in fish, which exceeds that found in amphibians and reptiles.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Manfred Schartl, Ronald B. Walter, Yingjia Shen, Tzintzuni Garcia, Julian Catchen, Angel Amores, Ingo Braasch, Domitille Chalopin, Jean-Nicolas Volff, Klaus-Peter Lesch, Angelo Bisazza, Pat Minx, LaDeana Hillier, Richard K. Wilson, Susan Fürstenberg, Jeffrey Boore, Steve Searle, John H. Postlethwait, Wesley C. Warren
URN:urn:nbn:de:bvb:20-opus-132152
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Humangenetik
Language:English
Parent Title (English):Nature Genetics
Year of Completion:2013
Volume:45
Issue:5
Pagenumber:567-572
Source:Nature Genetics 2013 45, 5, 567-572. doi:10.1038/ng.2604
DOI:https://doi.org/10.1038/ng.2604
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 612 Humanphysiologie
Tag:evolutionary biology; genomic analysis; genomics
Release Date:2016/06/11
Licence (German):License LogoCC BY-NC-SA: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Weitergabe unter gleichen Bedingungen